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Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants

Identifieur interne : 001466 ( Main/Exploration ); précédent : 001465; suivant : 001467

Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants

Auteurs : Joshua R. Buser [États-Unis] ; Jennifer Maire [États-Unis] ; Art Riddle [États-Unis] ; Xi Gong [États-Unis] ; Thuan Nguyen [États-Unis] ; Kerst Nelson [États-Unis] ; Ning Ling Luo [États-Unis] ; Jennifer Ren [États-Unis] ; Jaime Struve [États-Unis] ; Larry S. Sherman [États-Unis] ; Steven P. Miller [Canada] ; Vann Chau [Canada] ; Glenda Hendson [Canada] ; Praveen Ballabh [États-Unis] ; Marjorie R. Grafe [États-Unis] ; Stephen A. Back [États-Unis]

Source :

RBID : ISTEX:14F3C9DB140E18F2C7CA49EB99AF20179071F320

Abstract

The major form of magnetic resonance imaging–defined white matter injury (WMI) comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is poorly defined. We hypothesized that myelination failure associated with diffuse WMI involves an aberrant injury response linked to arrested preoligodendrocyte (preOL) maturation in reactive astrocyte‐rich lesions.

Url:
DOI: 10.1002/ana.22627


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<div type="abstract">The major form of magnetic resonance imaging–defined white matter injury (WMI) comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is poorly defined. We hypothesized that myelination failure associated with diffuse WMI involves an aberrant injury response linked to arrested preoligodendrocyte (preOL) maturation in reactive astrocyte‐rich lesions.</div>
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